Mintz advised the underwriters in connection with a $661 million public offering by Praxis Precision Medicines of 2,543,800 shares of common stock (which includes 331,800 shares of common stock issued pursuant to the exercise in full by the underwriters of their option to purchase additional shares of common stock) at a public offering price of $260.00 per share. The aggregate gross proceeds to Praxis Precision Medicines from this offering were approximately $661 million before deducting underwriting discounts and commissions and other offering expenses.

Piper Sandler, TD Cowen, Guggenheim Securities, and Truist Securities acted as joint book-running managers for the offering. LifeSci Capital, Baird, and Oppenheimer & Co. acted as lead managers for the offering. H.C. Wainwright & Co. and Needham & Company acted as co-managers for the offering.

The Mintz capital markets team included John Rudy, Nishant Dharia, Sam Silver, Gianna Nappi, Jocelyn Sun, and Michelle St Francis. Joanne Hawana provided regulatory advice and Edmund Koundakjian, Ph.D. provided intellectual property advice. Ari Feder provided tax advice. Members of the Mintz team are based in the Boston, New York, Washington, DC, and San Diego offices.